Whey protein

No significant difference in acne was observed in whey protein supplementation: Sompochpruetikul K, Khongcharoensombat T, Chongpison Y, Rittirongwattana W, Asawanonda P, Noppakun N, et al. Whey protein and male acne: A double-blind, randomized controlled trial. J Dermatol. 2024; 00: 1–4. https://doi.org/10.1111/1346-8138.17109 Contrary to the above, a 2-year randomized control trial (RCT) examining whey protein ingestion and bone health in postmenopausal women determined that high whey consumption resulted in higher serum IGF-1 levels, 7.3% at 1 year and 8% at 2 years. https://pubmed.ncbi.nlm.nih.gov/22892437 Hoppe, C., Mølgaard, C., Dalum, C., Vaag, A., & Michaelsen, K. F. (2009). Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. European journal of clinical nutrition, 63(9), 1076–1083. https://doi.org/10.1038/ejcn.2009.34 Hoppe, C., Mølgaard, C., Juul, A., & Michaelsen, K. F. (2004). High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. European journal of clinical nutrition, 58(9), 1211–1216. https://doi.org/10.1038/sj.ejcn.1601948 This case-control study provides evidence of a positive association between whey protein consumption and acne risk. Muhaidat, J., Qablan, A., Gharaibeh, F., Albataineh, G. H., Abdo, N., Alshiyab, D., & Al-Qarqaz, F. (2024). The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan. Dermatology research and practice, 2024, 2158229. https://doi.org/10.1155/2024/2158229

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"Conclusion: This study showed the onset of acne with the progressive use of protein-calorie supplementation, in a two-month period. It is suggested that this type of supplementation be discouraged." Pontes, Thaís de Carvalho et al. “Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa--PB.” Anais brasileiros de dermatologia vol. 88,6 (2013): 907-12. doi:10.1590/abd1806-4841.20132024